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Acute Kidney Injury Marker – Bioporto

NGAL (Neutrophil Gelatinase-Associated Lipocalin, Lipocalin-2, Siderocalin) is a small protein expressed in neutrophils and certain epithelia, including the renal tubules. Renal expression of NGAL is dramatically increased in kidney injury from a variety of causes, and NGAL is released into both urine and plasma. NGAL levels rise within 2 hours of the insult, making NGAL an early and sensitive biomarker of kidney injury.

Under normal conditions, NGAL levels are low in urine and plasma, but they rise sharply from basal levels in response to kidney injury and peaks within a very short time – as much as 24 hours or more before any significant rise in serum creatinine. The finding of a raised urinary or plasma level of NGAL cannot be independently diagnostic of any single pathology, since a variety of independent pathologies (e.g. inflammation, infection and certain types of cancer) are associated with raised levels of urinary or plasma NGAL.

NGAL is available exclusively from Bioporto through CPC in the following formats:

  • Human NGAL Rapid ELISA Kit
  • The NGAL Test
Human NGAL Rapid ELISA Kit:

Key features

  • 1-hour rapid assay format
  • For in-vitro diagnostic (IVD) use
  • Measures in urine, plasma and serum
  • All reagents are ready to use
  • Automation possible on open ELISA workstations
  • Assay dynamic range is 100-fold
The NGAL Test:

Assay specifications

  • Method: Particle-enhanced turbidimetric immunoassay
  • Sample: Urine and EDTA plasma
  • Sample stability: If the assay cannot be performed within 24 hours or specimens are to be shipped, freeze the specimens at -20°C or below. For long-term storage of specimens, -70°C or below is recommended.
  • Measuring range: 25 to 5,000 ng/mL
  • Assay time: 10 minutes (Hitachi 917) (Can vary based on analyzer model)
  • Shelf life: 24 months from manufacturing
  • Open vial stability: 30 days
  • On board stability: 30 days (when refrigerated)

For more details, please visit – www.bioporto.com