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Molecular Diagnostics & Research

The EUROArray System: (Innovative microarrays for molecular diagnostics (IVD)

Principle of DNA Microarray analysis

DNA Microarrays consist of DNA molecules (probes) which are applied to a solid carrier material, such as glass, as microscopically small spots located at defined positions. The probes differ from one another by their DNA sequence – the order of their building blocks (nucleotides with the bases adenine, A; cytosine, C; guanine, G; thymine, T). When the DNA of a patient contains segments that match the microarray probes, the complementary DNA regions bind together – they hybridize. This binding is measured via a computer-generated reading and evaluated as a positive signal with EUROArrayScan system.

Benefits of EUROArray system:

  • Ready-to-use PCR components.
  • Simple procedure.
  • Standardised incubation using established TITERPLANE™ Technique.
  • Integrated control reactions secure sensitivity and specificity for every test sample.
  • Fully automated standardised evaluation, interpretation and archiving of results (EUROArrayScan software).
  • No DNA isolation with EUROArray Direct: the analysis is performed  directly from pretreated blood.
  • Complete process from receipt of samples to issuing of results is IVD validated and CE labelled (DNA extraction, test kits, microarray scanner, software).
  • Pre-prepared LIMS connection.

Reliability of analysis is ensured by many controls

  • Hybridization specificity control – the PCR products have bound specifically to the DNA probes.
  • Cross contamination control – there was any cross contamination from one test field to the other.
  • DNA positive control – the patient DNA was intact and present in sufficient quantity.
  • PCR positive control – PCR was successful (functioning of primers and PCR conditions).
  • Negative control (automatically included) – the analysis was performed correctly and there are no false positives.
EUROArray test systems Indication Features
HLA-B27 Direct Bechterew‘s disease Highest sensitivity: detects all known HLA-B*27 alleles;
Improved specificity: differentiates non-disease-
associated HLA-B*27 alleles
HLA-DQ2/DQ8 Celiac disease Detects all alleles relevant for HLA-DQ2/DQ8
HLA-Cw6 Psoriasis Detects all worldwide relevant HLA-C* 06 alleles
Haemochromatosis (4 SNP)
Haemochromatosis (2 SNP)
Haemochromatosis Detects H63D, C282Y, S65C and E168X
Detects H63D and C282Y
FV/FII Direct, FV

Direct, FII Direct
Detects point mutations in the factor V gene (factor
V Leiden, 1691 G>A) and/or in the factor II
(prothrombin) gene (20210 G>A)
EuroArray HPV HPV Detects and differentiates all 30 relevant HPV
subtypes in one step (Low Risk & High Risk)
EuroArray HLA-
Detects HLA-B57:01 allele